Symptoms of Autoimmune Hemolytic Anemia with Thermal Hemolysins
This form of autoimmune hemolytic anemia, as a rule, begins gradually, in more rare cases, an acute onset is possible, the same as in the agglutinin form. The hemoglobin content is reduced to 40-60 g / l. The patient may be slightly jaundiced, although with this form of jaundice is less than with agglutinin forms of anemia. The spleen is enlarged in almost half of the patients, but this increase is not significant. Also in 50% of cases in patients with enlarged liver. The main feature of the hemolysin form of autoimmune hemolytic anemia is the excretion of black urine. At the same time in the urine reveal a large amount of protein. Hemoglobinuria is observed relatively rarely and not all patients with a hemolysin form of autoimmune hemolytic anemia, but hemosiderin is constantly detected in a number of patients. The level of bilirubin, as a rule, increases slightly, in most cases even is within the normal range.
Sometimes the hemolysin form of the disease is complicated by peripheral venous thrombosis. Possible attacks of abdominal pain associated with thrombosis of small mesenteric vessels.
Diagnosis of Autoimmune Hemolytic Anemia with Thermal Hemolysins
The blood picture in this pathology is often similar to that in agglutinin forms of autoimmune hemolytic anemia. Often a large number of microspherocytes is detected in the blood. The number of leukocytes in most patients is increased, often there is a shift in the leukocyte formula to myelocytes. Platelet count is normal.
Differential diagnosis of the hemolysin form of autoimmune hemolytic anemia is primarily carried out with Markiafau-Michele’s disease.