What is a Lymphocytoma of the Lymph Node?
Lymphocytoma of the lymph node is often diagnosed as chronic lymphocytic leukemia or as lymphosarcoma. Like other lymphocyte forms, this benign non-leukemic form of lymphatic proliferation lasts for many years. Initially, this lymphocytoma is often a random finding: one or several enlarged lymph nodes are detected, new nodes are gradually involved in the process. Not only peripheral, but also visceral lymph nodes can be affected.
Pathogenesis during Lymphocytoma of the Lymph Node
In the lymph node, tumor proliferation can be both diffuse and nodular, and, as in spleen lymphocytoma, nodular proliferates located on the site of follicles and outside of them have the appearance of clusters of mature cells of the same size and shape. Cytologically these are lymphocytes. In the bone marrow, the lymphatic tumor spreads slowly, more often it grows nodular, and at first proliferates may be isolated. Lymphocytosis in the bone marrow does not exceed 30% for a long time.
Diagnosis of Lymphatic Lymphocytoma
Lymphocytoma is often diagnosed at the stage of generalization, when lymph nodes of several peripheral groups are involved in the process, including visceral, the spleen is significantly enlarged and often dense and the liver is slightly enlarged. In the bone marrow, and at this stage, there can only be individual lymphatic proliferates, moderate leukocytosis in the blood. Generalized lymphocytoma resembles a tumor form of chronic lymphocytic leukemia, differing from it by a small incidence of bone marrow and nodular proliferation in the lymph node.
Treatment of Lymphocytoma Lymph Node
Usually, treatment with cyclophosphamide, chlorbutine at the leukemization stage, as well as with chronic lymphocytic leukemia.
Despite the generalization of lymphocytoma, with an enlarged spleen, it is advisable to begin treatment with its removal. Often it leads to some decrease in lymph nodes, and most importantly, a large mass of the tumor is removed. In the future, supportive therapy with cyclophosphamide gives a good effect: 200 g orally every other day in a total dose of 1000–1400 mg followed by a break for 10–14 days.